TCGA project carried out a genomic analysis of 373 cancers of the endometrium, stratifying them into four distinct prognostic groups: polymerase and (POLE) ultra mutated, mismatch repair-deficient (MMRd), p53 mutant/abnormal (p53abn), and NSMP (non-specific molecular profile) [37,38]. This evidence concerns the gene TP53 and cancer.