However, both dePEGylated lipopeptides EKL0C and EKL1C, which are also derived from the S protein HR2 domain but conjugated with cholesterol, exhibited potent but variable inhibitory activity against infection from HIV-1 laboratory-adapted strains, and the inhibitory activity of EKL1C against HIV-1 laboratory-adapted strains was generally higher than that of EKL0C, which is consistent with the inhibitory activity against HCoV infection [12]. Here, PROS1 is linked to infection.