There were no significant differences among the ‘progressors’ and ‘non-progressors’ in terms of gender (p = 0.15), age (p = 0.29), BMI (p = 0.13), comorbidity index (p = 0.24), smoking status (p = 0.84), Still’s disease (p = 0.41), and mobility function (p = 0.13), as well as oxytocin (p = 0.59), leptin (p = 0.08) and estradiol (p = 0.94) levels. The gene discussed is LEP; the disease is systemic-onset juvenile idiopathic arthritis.