While the detailed molecular mechanisms still require further investigation, recent studies have revealed that interferon gamma (IFN-γ) and the chemokine ligand 9/10-chemokine receptor 3 (CXCL9/10-CXCR3) axis appear important in vitiligo via inhibiting melanogenesis, inducing apoptosis of melanocytes and further recruiting T cells to the skin [6]. The gene discussed is IFNG; the disease is vitiligo.