LAG3 and ovarian carcinoma: In malignant ascites of ovarian cancer patients, the lymphocyte composition showed higher expression of CD4 and CD8 T cells relative to immunosuppressive receptors such as LAG-3: lymphocyte-activation gene-3 (LAG-3), programmed death-1 (PD-1), T cell immunoglobulin and mucin-domain-containing-3 (TIM-3), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), particularly when compared to peripheral blood samples (15).