Existing literature highlights that malignant ascites and ovarian cancer can create a unique intraabdominal tumor microenvironment, characterized by anti-tumor immunity inhibition and heightened levels of immunosuppressive cytokines such as VEGF-A, IL-10, TGF-β1, and immune cells expressing immunosuppressive receptors such as LAG-3, PD-1, TIM, and CTLA-4 [14,30]. The gene discussed is VEGFA; the disease is ovarian cancer.