To confirm that the effects of resveratrol on oxidative stress and SIPS were due to the up-regulation of Sirtuin-1, it would be of interest to over-express Sirtuin-1 in ECFCs using lentivirus infection and to treat the ECFCs with nicotinamide, an inhibitor of Sirtuin-1. This evidence concerns the gene SIRT1 and lentivirus infection.