In this regard, Gal-1 has been associated with type 2 diabetes [120], while Gal-3 has been correlated to both type 1 and type 2 diabetes [121,122,123], with a suggested role for this galectin in mediating the chronic inflammation underlying the progression from prediabetes to the diabetic stage [124]. This evidence concerns the gene LGALS1 and type 2 diabetes mellitus.