Further interrogation of astrocytic markers that have been implicated in neuronal excitotoxicity and epilepsy, such as aquaporin-4 (AQP4) and inwardly rectifying potassium Kir4.1 channels [115], in patients with mitochondrial disease would better inform the glial pathological changes that could be involved in seizure-associated activity and neurodegeneration in mitochondrial epilepsy. Here, AQP4 is linked to epilepsy.