SPINK2 and acute myeloid leukemia: Although these observations suggested the role of SPINK2 in ferroptosis-related pathways, definitive evidence of its involvement in ferroptosis regulation in AML is necessary by performing ferroptosis-specific analyses, such as a determination of lipid peroxidation levels and mitochondria morphological changes, as well as an assessment of cell death reversal by ferrostatin-1, a specific ferroptosis inhibitor [17].