Although the pathophysiological significance of this difference between the retina and hippocampus of Tg2576 AD mice in response to 12A12mAb administration has yet to be elucidated, it is noteworthy that the same endocytic pathway that crucially regulates the BACE1-triggered APP degradation at synapses is engaged by 12A12mAb in both tissues to limit the side-by-side Aβ production. This evidence concerns the gene BACE1 and Alzheimer disease.