BIN1 and Alzheimer disease: In this context, a relevant observation of the present work is that 12A12mAb exerts an anti-amyloidogenic effect in vivo [15,44] both in the CNS and neurosensory retina (Supplementary Figure S1) along a pathway(s) involving several AD-associated risk variants coding for BIN1 and RIN3 (Figure 1 and Figure 2), two crucial protein regulators of clathrin-mediated endocytic trafficking [98,143].