As shown (Figure 2A,B), the intensity band of RIN3 showed a slight but statistically significant elevation in the hippocampus from Tg2576 AD mice when compared to age-matched wild-type littermates (* p < 0.05; Tg2576 versus wild-type), in agreement with the co-distribution of APP/BACE1 high signals we contextually detected in synaptic fractions (Figure 1A–D). This evidence concerns the gene BACE1 and Alzheimer disease.