As shown in Figure 1E,F and regardless of the analyzed area (hippocampus versus retina), the steady state expression level of neuron-specific BIN1 isoform (65 kDa BIN1.1) was significantly reduced in Tg2576 AD mice when compared with littermate wild-type group (hippocampus **** p < 0.0001; retina *** p < 0.0005, Tg2576 versus wild-type). This evidence concerns the gene BIN1 and Alzheimer disease.