2.1. 12A12mAb Immunization Antagonizes the BACE1-Initiated Amyloidogenic Processing of APP by Altering the Protein Expression of Neuron-Specific BIN1 and RIN3 Endocytic Adaptors, Both in Hippocampus and Retina from Tg2576 AD Mice. The gene discussed is BACE1; the disease is Alzheimer disease.