APP and Alzheimer disease: On the one hand, immunization of symptomatic Tg2576 AD mice normalizes in the retina even up to the control values the steady state expression levels of BIN1 and RIN3, which regulate in a reciprocal way (inhibition and stimulation, respectively) the APP/BACE1 sorting convergence into Rab5-positive early endosomes (i.e., initial APP cleavage by BACE1 leading to Aβ generation) [67,68,91,144].