RAB5A and Alzheimer disease: As shown in Figure 3C,D, a substantial decrease in the active form of Rab5 was found in Tg2576 AD mice when compared with wild-type control group (** p < 0.01; Tg2576 versus wild-type), whereas no statistically significant effect was detected in the immunized cohort following 12A12mAb treatment (p > 0.9999; Tg2576+mAb versus Tg2576).