Despite its proposed role in regulating the intracellular endo-lysosomal transport of β-secretase and APP, no change in immunoreactivity levels among three experimental groups (p > 0.9999) was detected when the filters were probed with a specific antibody for CD2AP (Figure 2C,D), indicating that this protein is not involved in the anti-amyloidogenic effect of 12A12mAb immunization both in hippocampal and retinal synapses of Tg2576 AD mice. Here, APP is linked to Alzheimer disease.