Interestingly, 12A12mAb administration significantly normalized the changes in the RIN3 signals only in the retina (*** p < 0.0005; Tg2576+mAb versus Tg2576) since no noticeable modulation was contextually detected in the corresponding hippocampus from Tg2576 AD cohort when compared to its not-immunized counterpart (p > 0.9999; Tg2576+mAb versus Tg2576). Here, RIN3 is linked to Alzheimer disease.