Interestingly, we have also found out that systemic treatment with 12A12mAb exerts a local anti-amyloidogenic effect both in the hippocampus and retina of transgenic AD mice, supporting the finding that a dynamic, positive feed-forward regulation between APP/Aβ and tau cleavage drives the neurodegeneration in this disease [46,47]. This evidence concerns the gene APP and Alzheimer disease.