On the contrary, in retinal samples, a dramatic decrease in Rab5 immunoreactivity was detected in Tg2576 AD mice when compared with wild-type control group (**** p < 0.0001; Tg2576 versus wild-type); following 12A12mAb administration and just as detected for BIN1 (Figure 1E,F) and RIN3 (Figure 2A,B), the steady state expression level of Rab5 was significantly recovered in Tg2576 AD cohort when compared to its not-immunized counterpart (**** p < 0.0001; Tg2576+mAb versus Tg2576). This evidence concerns the gene BIN1 and Alzheimer disease.