MAPT and Alzheimer disease: It is noteworthy that 12A12mAb immunization significantly decreased the level of L-lactate both in the hippocampus and retina from Tg2576 AD mice, indicating that in vivo treatment with this tau antibody strongly normalized the GLU metabolism along the glycolytic route approximately to control values (hippocampus **** p < 0.0001; retina **** p < 0.0001; Tg2576+mAb versus Tg2576).