MAPT and Alzheimer disease: From a translational point of view, these results seem to fit well with our metabolic data hinting at tau-dependent energetic changes of glucose utilization along the glycolytic (i.e., lactate production) and mitochondrial pathways as key mediators of the neuroprotective and anti-amyloidogenic effect of 12A12mAb immunization in Tg2576 AD animal model.