However, when this balance is disturbed, due to the imbalanced secretion of IL-1β, IL-6, IL-12, IL-18, TNF-α, and chemokine (C–C motif) ligand 2 (CCL2) chemokine, liver function is impaired, and NAFLD develops [59,75]. Here, IL1B is linked to metabolic dysfunction-associated steatotic liver disease.