It works through a variety of methods, including the selective delivery of DM1 (a microtubule-inhibitory-agent derivative of maytansine) to HER2-positive tumor cells, the trastuzumab-mediated suppression of HER2 signaling, the prevention of the shedding of the HER2 extracellular domain, and the induction of ADCC [32,33,34]. Here, ERBB2 is linked to neoplasm.