Booiman et al. (2014) reported that the TREX1 531C/T polymorphism had no effect on the progression of HIV-1 infection [23], while the study by Pontillo et al. (2013) described that there was no difference in the frequency of the polymorphism between individuals infected with HIV-1 and a control group, but the authors did not assess the progression of the infection [26]. This evidence concerns the gene TREX1 and HIV-1 infection.