The promising role of SIRT6 regulation is indicated to support the treatment of: atherosclerosis [65]; diabetic atherosclerosis [66]; diabetes-associated inflammatory diseases [67]; diabetic nephropathy [68]; adipose tissue inflammation [69]; oxidative stress in the heart triggered by high-fat diet-induced obesity [70] and osteoarthritis [61,71]. This evidence concerns the gene SIRT6 and diabetes mellitus.