The promising role of SIRT6 regulation is indicated to support the treatment of: atherosclerosis [65]; diabetic atherosclerosis [66]; diabetes-associated inflammatory diseases [67]; diabetic nephropathy [68]; adipose tissue inflammation [69]; oxidative stress in the heart triggered by high-fat diet-induced obesity [70] and osteoarthritis [61,71]. Here, SIRT6 is linked to obesity due to melanocortin 4 receptor deficiency.