The functional relevance of MCT8 and OATP1C1 expression at the cellular level in the striatum in primates remains elusive as yet; however, since they are critical for the TH nuclear receptor-mediated signaling [60,61], one might assume that those cells would be affected by some kind of hypothyroidism throughout development and postnatal life. The gene discussed is SLC16A2; the disease is hypothyroidism.