Speaking of endothelial permeability, the ANP/NPR-A system plays an essential function with a direct impact on the regulation of circulating blood volume: in murine models, the decreased endothelial expression of the NPR-A gene induced by genetic engineering techniques, led to hypertension, increased plasma volume, and reduced clearance of albumin from the vascular tree [117]. This evidence concerns the gene NPR1 and hypertensive disorder.