Regarding the anti-RAAS activity, Cataliotti et al. showed that in congestive heart failure patients, furosemide and BNP had favorable cardiovascular hemodynamic actions compared with furosemide alone, probably because the suppression of the RAAS may have prevented the anti-natriuretic actions of angiotensin II on the proximal tubule and of aldosterone on the distal tubule [112]. This evidence concerns the gene NPPB and congestive heart failure.