REN and heart failure: The importance of renal effects, and possible therapeutic implications related to the use of NPs, emerged from a trial that evaluated the effects in animal models, associated with the administration of a natriuretic peptide antagonist on A and B receptors termed HS-142-1 [154]: in both healthy animals and animals in which heart failure was experimentally induced, the drug was able to inhibit diuresis and natriuretic peptide-mediated natriuresis, elevate vascular resistance in the renal circulation, and increase the concentration of renin, aldosterone, and catecholamines [155].