WNT1 and microcephaly: Previously, we reported that Wnt1-Cre; Fam20bf/f mice, in which the Fam20b-catalyzed synthesis of GAG chains in CNCC-derived mesenchyme was disrupted, displayed a variety of craniofacial malformations, including cleft palates, microcephaly, micrognathia, cranial suture widening, and decreased mineralization of the cranio–maxillofacial bone and temporomandibular joint [29].