Platelet-derived growth factor receptors alpha and beta (PDGFRα and PDGFRβ) are membrane receptors that play a key role in a variety of diseases, such as cancer [1,2,3,4,5], immune-mediated pathologies, such as systemic sclerosis (SSc) [6,7,8,9,10], and viral infection [11], by exerting function on the transduction of extracellular signals into the cell. The gene discussed is PDGFRB; the disease is systemic sclerosis.