Although its PTP1B inhibitory potency was higher in vitro (50% PTP1B inhibition at 0.5 μM concentration) than in intact living cells, claramine elicited insulin-mimetic effects in neuronal cells by enhancing the phosphorylation of IRβ, Akt, and GSK3β and was able to control glycemic levels in a murine diabetes model, together with a stronger but less prolonged appetite suppressing effect than trodusquemine [139]. This evidence concerns the gene PTPN1 and diabetes mellitus.