Galectin-3 is also an agonist of Toll-like receptor 4 (TLR4) and can regulate the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, promoting inflammasome assembly and activation, which contributes to enhanced inflammation and tissue damage in viral infections [31,35,36]. The gene discussed is LGALS3; the disease is viral infectious disease.