S100B and brain injury: S100B levels in biological fluids constitute a recognized clinical parameter to evaluate patients with acute brain injury [52,53,54,55,56,57,58,59,60], and a special emphasis has been recently placed on mild traumatic brain injury [61,62,63,64,65,66,67,68,69,70,71] since S100B levels have been proposed as a reliable screening tool in this pathological condition.