Interestingly in this respect, the range of diseases where S100B is putatively involved in pathogenic processes, at least based on results in experimental models, is now enlarging outside the nervous system (e.g., muscular dystrophy, obesity, diabetes, ocular disorders); potentially, it is expected to parallel the cellular distribution of the protein, which is definite but significant [3,5]. Here, S100B is linked to obesity due to melanocortin 4 receptor deficiency.