The silencing of S100B in astrocytes derived from the SOD1-G93A mouse model inhibited several genes commonly overexpressed in ALS astrocytes (TNF-α, C-X-C motif chemokine, chemokine (C-C motif) ligand 6, Glial Fibrillary Acidic Protein). Here, S100B is linked to amyotrophic lateral sclerosis.