It has been revealed that IL-6 suppresses cell proliferation via the stimulation of JAK–STAT signaling, but, on the other hand, this cytokine, together with the epidermal growth factor receptor (EGFR), can synergistically influence the up-regulation of the MAPK and PI3K/AKT pathways, resulting in enhanced cancer cell migration [60]. This evidence concerns the gene AKT1 and cancer.