CD4 and B-cell chronic lymphocytic leukemia: Furthermore, CD3+ CD4+ T lymphocytes present a higher CD54 expression (7.04 ± 0.25 vs. 2.51 ± 0.5 in controls; p < 0.0001) (Figure 4B,D), while the IFN-γ production by CD3+ CD4+ cells are substantially comparable between CLL and healthy controls (26.06 ± 4.50 vs. 20.65 ± 2.97, respectively).