Although the mechanisms underlying the immune-mediated control of tumour cells in human models are still largely undefined, the involvement of natural killer cells (NK), cytotoxic CD8+ T lymphocytes (CTL) and Interferon (IFN)-γ dependent pathways in the control of tumour progression have been widely recognised [9,10,11,12,13,14,15,16,17,18]. This evidence concerns the gene IFNG and neoplasm.