No differences were found in the expression of the activating molecules Nkp46 (CD335), Nkp30 (CD337), Nkp44 (CD336) and NKG2D [27,29,30] (Figure 9A).The expression of the activating receptor 2B4 (CD244) [65,66] is decreased in CLL subjects (86.63 ± 4.82 vs. 99.77 ± 0.11 in healthy controls; p < 0.0005) (Figure 9A). The gene discussed is KLRK1; the disease is B-cell chronic lymphocytic leukemia.