An increased expression of CD54 (13.26 ± 0.80 vs. 6.72 ± 1.39 in healthy controls; p < 0.0001) and a higher IFN-γ production (62.94 ± 5.97 vs. 34.84± 4.81 in healthy controls; p < 0.005) by CTL characterise CLL subjects (Figure 4A,C, respectively). This evidence concerns the gene ICAM1 and B-cell chronic lymphocytic leukemia.