In CLL subjects, analysis of the CTL receptor repertoire revealed an increased KIR2S2 (CD158j) expression (3.66 ± 1.12 vs. 0.65 ± 0.29 in healthy controls), while no difference was observed for the other receptors (CD335, CD336, CD337, NKG2D, CD244, CD158e1/e2 and CD85k) (Figure 10A). Here, KIR3DL1 is linked to B-cell chronic lymphocytic leukemia.