Based on our data, we can speculate that the increased IFN-γ production by CTL may induce APM molecules in circulating T lymphocytes of CLL individuals, also affecting surface calreticulin expression, usually associated with the occurrence of an overloading of the intracellular protein folding by B and T cells, as well as with immunogenic cell death processes [63]. The gene discussed is CALR; the disease is B-cell chronic lymphocytic leukemia.