ITGAV and familial pancreatic carcinoma: Similarly, the integrin ITGαv (related to liver metastasis) was increased in EXOs isolated from the plasma of pancreatic cancer patients with liver metastasis, with respect to patients with no metastasis or lung metastasis; interestingly, upon diagnosis, the EXO-associated ITGαv levels were higher in cancer patients who successively developed liver metastasis compared with control subjects or patients with no liver metastasis within three years of diagnosis [33,35].