VEGF-A loaded in EVs, released by ex vivo cultured patient-derived glioblastoma stem-like cells, can also play a role in inducing higher permeability of the endothelium, as demonstrated in a model of glioblastoma multiforme [105]; in a similar model, it is the Semaphorin3A expressed on the surface of EVs isolated from patient-derived glioblastoma cells that induces an increased vascular permeability [106]. Here, VEGFA is linked to glioblastoma.