The downregulation of the NF-κB/MAPK signaling pathway was postulated to decrease pro-inflammatory cytokines such as IL-6, TNF-α, IL-1β, CXCL10/IP-10, CCL2/MCP-1, and IL-8, suggesting that it may prevent cytokine storm in COVID-19 [55]. The gene discussed is NFKB1; the disease is COVID-19.