PLAC8 and cancer: MAFF is a hypoxia-induced gene that promotes the metastatic and self-regenerative capacity of cancer cells [34,35], while PLAC8 contributes to the proliferative and invasive characteristics of malignancies via Wnt/β-Catenin signaling or cell-cycle regulatory pathways [36,37]; however, the prognostic significance of FAM177A1 in HCC remains to be elucidated in subsequent studies.