G6PC1 and Hyperglycemia: Consistently with the hyperglycemia (Figure 2B) and with the inactivation of AKT signaling at milder and higher doses CPF (Figure 4D–F), we investigated the expression of two of main important transcripts modulating the production of glucose by the liver, the glucose-6-phosphatase (G6pase), and the phosphoenolpyruvate carboxykinase 1 (Pck1).