SIGMAR1 and status epilepticus: In PTZ-induced seizures and kainic-acid-induced status epilepticus models, compounds with agonist activity to Sigma1R (SKF-10.047, dextromethorphan, and carbetapentane) and Sigma1R positive modulators (SKF83959, SOMCL-668, and E1R) showed anticonvulsant properties.