SIGMAR1 and Seizure: To prove our main hypothesis of Sigma1R involvement in GABAA receptor-dependent pharmacological effects, we performed a series of experiments on BALB/c and ICR mice using Sigma1R ligands to study anxiolytic effects of benzodiazepine tranquilizers diazepam (1 mg/kg i.p.)and phenazepam (0.1 mg/kg i.p.)in the elevated plus maze test, the anticonvulsant effects of diazepam (1 mg/kg i.p.)in the pentylenetetrazole-induced seizure model, and the hypnotic effects of pentobarbital (50 mg/kg i.p.).