Although the precise physiological function of Sec62 is not completely understood, this protein seems to enhance the stress tolerance, migration, and invasive potential of SEC62-overexpressing cells—the three hallmarks of cancer—resulting in high rates of lymph node metastasis and poorer overall prognoses [14,15,16,17,18,19]. This evidence concerns the gene SEC62 and metastatic malignant neoplasm in the lymph nodes.