CDK5, on the other hand, has been functionally involved in the regulation of hippocampal dendrite morphology [101], in the regulation of both hippocampal neurotransmitter release and amplitude of hippocampal field EPSP slope [102], and CDK5 has been also proposed as a possible molecular regulator of amyloid beta production and in the mechanisms associated to the pathogenesis of Alzheimer’s disease [98,103]. This evidence concerns the gene CDK5 and early-onset autosomal dominant Alzheimer disease.