LRRK2 and Parkinson disease: Patients carrying some common LRRK2 mutations, such as G2019S, R1441C and Y1699C, all present the typical late-onset PD symptoms, including non-motor symptoms; Lewy body disease; and degeneration of DA neurons in the SNc with neurofibrillary tangles, abnormal tau deposits and neuronal intranuclear inclusions [37,42,43].