Studies have found that when cells lose the protection of SIRT6, excessive lipid accumulation will damage the redox system of cells; stimulate the production of reactive oxygen species (ROS); and attack mitochondria with regard to its permeability, membrane potential, and structural changes, which leads to cell inflammation or apoptosis and promotes NAFLD to continue to develop [14,15]. Here, SIRT6 is linked to metabolic dysfunction-associated steatotic liver disease.