Indeed, the synergistic activation of both T and NK cell anti-tumor response, via MHC class I chain-related protein A/B (MICA/MICB) stress molecules, Stimulator of Interferon Genes (STING) agonists, or IL-2 superkines, were found to be highly effective in controlling tumor growth, especially in MHC-I-deficient tumors and in poorly immune infiltrated microenvironments [80,92]. This evidence concerns the gene MICB and neoplasm.