During the development of psoriasis phenotype in AGR129 mice after xenotransplantation, upregulation of markers such as intercellular adhesion molecule 1 (ICAM-1), MHC class II, endothelial cell adhesion molecule-1 (PEACAM-1) and pro-inflammation cytokines (TNF-α, Il-12 and IFN-γ) [43] has been observed. The gene discussed is ICAM1; the disease is psoriasis.