Recently, it has been found and validated that DUX4 can interact with several RNA-binding proteins (RBPs), such as complement C1q binding protein (C1QBP), serine- and arginine-rich splicing factor 9 (SRSF9; a known C1QBP interactor), RNA-binding motif protein 3 (RBM3), fused in sarcoma/translocated in liposarcoma (FUS/TLS), and splicing factor proline- and glutamine-rich (SFPQ). The gene discussed is RBM3; the disease is liposarcoma.