Other studies had the same results on the link between DUX4 and histone proteins, confirming and clarifying the essential role that DUX4 plays in regulating the proteins involved in chromatin remodeling and that, as a result, the aberrant expression of this protein causes a cascade of epigenetic events that favor the FSHD phenotype [115]. Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.