Similarly, in a study using human neuroblastoma cells (SK-N-MC), exposure to alcohol (34, 69, and 103 mM; notably, blood alcohol concentrations in alcohol abusers reach or exceed 69 mM) and acetaldehyde (54, 107, and 215 μM) showed a dose-dependent increase in the expression of BACE-1 and the C99 fragment of APP. This evidence concerns the gene BACE1 and neuroblastoma.