Chronic alcohol treatment increased locomotor activity and modulated mRNA levels of NMDA (increases) and GABAA (decreases) receptors in APP/PS1 mice brains. Alcohol elevated the hippocampal interstitial fluid Aβ40 levels with no changes in the Aβ42 levels.Conclusion: Chronic alcohol consumption aggravates AD-related pathology in the APPswe/PS1dE9 mice. This evidence concerns the gene PSEN1 and Alzheimer disease.