The different pathways and targets of alcohol-mediated neurotoxicity in AD that have been postulated are summarized in Figure 1 and include Toll-like receptors, Akt/mTOR pathway, cAMP response element-binding protein (CREB) phosphorylation pathway, glycogen synthase kinase 3-β (GSK3β), cyclin-dependent kinase-5 (CDK5), and insulin-like growth factor type-1 (IGF) receptor genes highly expressed in the various regions of the brain, such as the hypothalamus, temporal lobe, and cerebellum [50,51,52,53]. Here, CDK5 is linked to Alzheimer disease.