AGER and Alzheimer disease: Similarly, a chronic binge of alcohol (once daily for two months) to C57BL/6 and APPswe/PS1dE9 AD mice resulted in increased permeability of the BBB, likely due to downregulation of tight junction proteins (ZO-1, VE-cadherin, and occludin), and altered the levels of Aβ transporters LRP1 and RAGE [32].