Cabernet Sauvignon improved spatial memory and reduced neocortical Aβ40 and Aβ42 or AD-type plaque burden in the Tg2576 mice. Alcohol treatment had no effect on any of the measured parameters. Cabernet Sauvignon or alcohol did not change the serum levels of bilirubin, AST, and ALT in the Tg2576 mice.Conclusion: Cabernet Sauvignon at moderate doses protects from Aβ-induced neurotoxicity and improves cognitive recognition in the Tg2576 mice, which may be due to the antioxidants and polyphenols such as resveratrol. The gene discussed is GPT; the disease is Alzheimer disease.