Adolescent intermittent ethanol (AIE) treatment regimen (2 days on/2 days off) at a dose of 5 g/kg/d (25% w/v in water) by oral gavage in male and female 3xTg-AD mice from postnatal 25th to 55th day, followed by a period of being unperturbed for the next 145 days, showed an increased cognitive decline, significant increase in Aβ and tau pathology, and proinflammatory cytokines in adult female 3xTg-AD mice. The gene discussed is MAPT; the disease is Alzheimer disease.