AIE altered the mouse behavior and increased Aβ42, p-tau (Thr181), and various cytokines in female 3xTg mice brains. AIE also altered the expression of microglial DAM genes in female 3xTg mice.Conclusion: Alcohol intake in adolescence promotes the early onset of AD pathology by triggering proinflammatory microglial signaling. This evidence concerns the gene MAPT and Alzheimer disease.