PSEN1 and Alzheimer disease: In this study, the dose-dependent effects of alcohol on AD pathology were examined in two-month-old APP/PS1 2xTg AD male mice treated with a liquid diet containing different concentrations of alcohol (0.5, 1, 2, 3, and 4% w/v equivalent to 2.2, 4.5, 9, 13, and 18 g/kg/d) daily for five weeks.