BACE1 and neuroblastoma: Using stable human cells lines (HEK293 embryonic or SH-SY5Y neuroblastoma cells) that express mutant human APP and BACE-1, studies show that alcohol at different concentrations (up to 139 mM) increased the expression of APP, BACE-1, Aβ42, and Aβ40, demonstrating the ability of alcohol to increase APP processing and Aβ production in vitro [30] (Table 2).