In a study with 5.5-month-old male APP/PS1 AD mice mutated with human APP and PSEN1 genes, chronic alcohol feeding (20% w/v in water for 12 h/day for four consecutive days during the dark cycle) via a two-bottle choice drinking paradigm for 10 weeks resulted in brain atrophy and increased the frequency of smaller Aβ plaques in the APP/PS1 AD mice [31]. This evidence concerns the gene PSEN1 and Brain atrophy.