DAGLA and Alzheimer disease: Alcohol binge worsened cognitive impairment, accelerated AD pathology, and increased Aβ42 levels. Alcohol lowered CB2 RNA levels and increased the expressions of MAGL, with no change in DAGLα.Conclusion: Binge alcohol drinking during adolescence alters hippocampal ECS activity in adult mice. These altered ECS conditions could contribute to memory impairment. Binge alcohol also accelerates hippocampal Aβ in AD mice.