Among clinical parameters, including nasal secretion and serum IgE, IL-5, blood eosinophil/neutrophil, allergy, asthma, and nasal polyps, total IgE in nasal secretions was the only predictor of responder in multivariate models (odds ratio 4.76, 95% confidential interval 1.29–17.58). The gene discussed is IGHE; the disease is allergic disease.