The differences might be explained by specific features of each cell line LNCaP cells share characteristics with early-stage prostate cancer (adenocarcinoma), while PC-3 is a cell line that resembles a small cell neuroendocrine carcinoma (SCNC), including the expression of the androgen receptor (AR) and prostate-specific antigen (PSA) whereas PC-3 cells do not express these proteins [48]. Here, AR is linked to Familial prostate cancer.