Finally, when we compared the genes downregulated in our patient with those published by Ortega-Recalde et al. in Curth-Macklin ichthyosis, two were concordantly downregulated (PHYHIP, PAMR1), while DCD, FABP4, PLIN1, SCGB1D2, SCGB2A2, ADIPOQ, G0S2, KRT19 and MUCL1, downregulated in our case, were upregulated in Curth-Macklin ichthyosis. This evidence concerns the gene ADIPOQ and ichthyosis.