LORICRIN and Palmoplantar keratoderma: In this study, we described the novel LORICRIN gene pathogenic variant: c.639_642dup with the first transcriptome analysis of lesional loricrin keratoderma epidermis, and a rare p.Gln4Ter variant in the same gene, as evidence that the haploinsufficiency of loricrin does not cause skin symptoms of LK.