C9 downregulates CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathways, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2), by suppressing CypA and CD147 expression in gastric cancer (GC) cells [21]. Here, MAPK8 is linked to gastric cancer.