NSCLC CSCs express specific stemness markers, including integrin α6, CD133, CD44, Nanog, Oct4, aldehyde dehydrogenase 1 (ALDH1), and Sox2, which are positively associated with aggressive biological behavior and poor prognosis in NSCLC [9,10,11]. The gene discussed is PROM1; the disease is non-small cell lung carcinoma.