The cell surface markers CD44, CD133, and integrin α6 play crucial roles in the growth, self-renewal, metastasis, and chemoresistance of NSCLC CSCs by regulating several signaling pathways, including the Notch, Hedgehog, Wnt, and STAT3 pathways [32,36,37,38]. The gene discussed is CD44; the disease is non-small cell lung carcinoma.