In conclusion, the dysregulation of IGF2BP3 plays a crucial role in tumor development and progression by affecting different features of human cancers, including tumor cell proliferation, migration, metastasis, chemotherapy resistance, radiosensitivity, and immune response (We summarized roles and targets of IGF2BP3 in various human cancers in Table S1; Full names of the genes mentioned in the text in Table S2). Here, IGF2BP3 is linked to cancer.