A study in mice showed that an increase in hepatic HMGB1 during fibrogenesis contributes to the pathogenesis of the disease by driving the scarring process, so that an increase in HMGB1 is not just the result of liver damage but is also a contributing event and, therefore, a possible target for preventing the onset of liver fibrosis [92]. Here, HMGB1 is linked to Hepatic fibrosis.