It is noteworthy that stress during early life (MS), increases the expression of pro-inflammatory cytokine genes (IL6 and IL1β) and HMGB1 in both the hippocampus and prefrontal cortex of animals, while the use of fluoxetine and exercise during adolescence can decrease the expression of IL6, IL1β and HMGB1 in both the hippocampus and prefrontal cortex in rats exposed to MS [150]. This evidence concerns the gene HMGB1 and myeloid sarcoma.