TNFRSF1B and type 2 diabetes mellitus: J Lin et al., in a cross-sectional study of 732 men with T2D, demonstrated that TNFRII levels were significantly higher in subjects with GFR < 60 mL/min/1.73 m2 with respect to GFR ≥ 90 mL/min/1.73 m2, and through multivariable logistic regression analysis they demonstrated that TNFRII together with triglycerides, fibrinogen, and VCAM were associated with increased odds of having a GFR < 60 mL/min/1.73 [34].