In light of this evidence, the main aim of the current study is to determine the serum concentrations of TNFRI, TNFRII, and KIM-1 in the 69 T2D patient cohort and evaluate if their combination with previously identified mitochondrial RNA expression data can constitute a novel panel that allows an enhancement of the diagnostic performance of DKD. The gene discussed is TNFRSF1A; the disease is type 2 diabetes mellitus.