Noting that the endothelium is closely linked to the initiation and propagation of IBD pathology, while distinctive features of the intestinal endothelium contribute to these conditions [135], Ferrari et al. [121] investigated C3G’s modulatory effects on in vitro inflammatory crosstalk between intestinal epithelial and endothelial cells, using Caco-2 and HUVECs cells. This evidence concerns the gene RAPGEF1 and inflammatory bowel disease.