SOST and osteoporosis: Curiously, serum sclerostin levels were significantly elevated in studies of children with severe HA [18]; therefore, romosozumab, a specific anti-sclerostin antibody that inhibits sclerostin-LRP5/6 interaction and that indirectly activates canonical Wnt signalling pathways and bone formation, may be effective in the pharmacological treatment of osteoporosis in PWH.