With respect to SLC3A2 involvement in gliomas, polyamine synthesis has been detected as enhanced in the pediatric type of diffuse intrinsic pontine gliomas (DIPG), thus increasing sensitivity to difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase 1 (ODC1), which is the rate-limiting step in polyamine synthesis. The gene discussed is ODC1; the disease is central nervous system cancer.