We considered many genes, but using a specific approach of prioritization, we delimited the scope of the studied genes to the top 10 candidate genes (APOE, PSEN1, INS, IL6, SQSTM1, SP1, HTT, LEP, HSPA4, BDNF), which comprise candidate genes of inverse comorbidity of HD and cancer. The gene discussed is SP1; the disease is Huntington disease.