A substantial number of genes (n = 35: APOE, IL6, CTSB, HSPA4, TP53, AKT2, AKT3, CASP3, CASP8, CASP9, BCL2, FAS, ATM, PARP1, BID, IKBKB, TRAF1, TRAF2, PIK3CA, APAF1, MCL1, NFKBIA, NGF, RAF1, CHUK, RIPK1, MAP3K5, ENDOG, BDNF, PIK3CB, DFFA, SP1, MAPK1, NRAS, NFKB1) were associated with endophenotypes (systolic/diastolic pressure, body mass index, C-reactive protein, serum cholesterol level, smoking behavior), which can be considered as risk factors of neurodegenerative diseases/cancer. The gene discussed is PIK3CA; the disease is neurodegenerative disease.