ALDH1A1 and acute myeloid leukemia: A high expression of ALDH1A1 in AML cells would be a selective advantage: (a) the enzyme is relatively resistant to inactivation from byproducts of lipid peroxidation, (b) it detoxifies a broad range of aldehyde substrates, particularly long-chain [5], (c) facilitates cell survival by enabling crucial functions of DNA repair [125].