CEBPB and leukemia: The capacity of NFκB to induce C/EBPβ expression is important for leukemia: ectopic expression of C/EBPβ was shown to activate lymphoid-myeloid transdifferentiation; in particular, when subjected to selective pressure to eliminate lymphoid cells, C/EBPβ-expressing B cells produced granulocyte-macrophage progenitor-like progenitors, which remained self-renewing and cytokine-independent, and continuously produced macrophages and granulocytes [72].