The interaction of inactivated OGG1 with NFκB, however, elicits the expression of several chemokines and cytokines that contribute to inflammation in addition to enabling innate immunity, they have the capacity to modulate RAS/NFκB dependent carcinogenesis, and to transform the microenvironment of malignant tumors [114,115,116,117]. Here, NFKB1 is linked to cancer.