Cultured breast cancer cells MDA-2J2 that are resistant to paclitaxel, doxorubicin, staurosporine, and multikinase inhibitor sorafenib, could be sensitized by ALDH1A1 gene silencing, demonstrating the capacity of ALDH1A1 to mediate resistance to a variety of antineoplastic pharmaceutical agents [39]. The gene discussed is ALDH1A1; the disease is breast carcinoma.