STAT3 and diffuse large B-cell lymphoma: Actually, in diffuse large B cell lymphoma, ALDH1A1 enhances phosphorylation of transcription factors STAT3 (signal transducer and activator of transcription 3) and NFκB, augmenting clonogenicity, suppressing caspase activity, and inducing resistance to the chemotherapeutic mixture consisting of cyclophosphamide, doxorubicin, vincristine, and prednisone [58].