CXCL8 and melanoma: In melanoma cells ALDH1A1, through the retinoic acid pathway, regulated the activation of NFκB and expression of C-X-C Motif Chemokine CXCL8; in co-cultures of melanoma with endothelial cells, the addition of a CXCL8 neutralizing antibody to endothelial cells dampened endothelial angiogenic features, both at the molecular level in terms of gene and protein expression of mediators of the Notch pathway, and at the functional level in terms of proliferation, scratch assay, tube formation and permeability [45].