CYBB and acute myeloid leukemia: NADPH oxidase-2 generates superoxide, which stimulates bone marrow stromal cells to transfer mitochondria to AML blasts through AML-derived tunneling nanotubes; this protects AML cells from apoptosis, and causes death to the mammalian host organism, as it was shown by mice that were intravenously injected with patient AML blast cells [106].