The finding that PFAS directly increase aldosterone biosynthesis and augment the effect of Ang II on aldosterone release should not be disregarded as small increases in the plasma concentrations of aldosterone within the physiologic range were shown to raise blood pressure in the general population of the Framingham Offspring study [29] and to be associated with the two main detrimental consequences of high blood pressure, i.e., left ventricular hypertrophy [30] and incident atrial fibrillation in the ARIC study [31]. The gene discussed is AGT; the disease is blood pressure trait.