Importantly, platelet phagocytosis could also be observed especially in specimens challenged with 20 ng/mL of Alpha and Delta recombinant spike proteins (Figure 4), a pathological process that has been previously described in the blood smears of patients with SARS-CoV-2 infection and reflecting intense monocyte activation and haemophagocytic lymphohistiocytosis [31], a frequent condition seen in patients with COVID-19 [32]. Here, CHMP5 is linked to COVID-19.