In keeping with our observations, the authors also found an increased SD of the cross-sectional monocyte area in patients with COVID-19, which is reflected by the enhanced MO-WZ value that we found in samples where SARS-CoV-2 recombinant spike proteins (except that of the Omicron variant) were added at the final concentration of 20 ng/mL, clearly reflecting a broader heterogeneity of monocyte volumes. Here, CHMP5 is linked to COVID-19.